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Article

The role of mouse adenovirus type 1 early region 1A in acute and persistent infections in mice.

Journal of virology - 1 Jul 1998

Smith K, Brown C C, Spindler K R

Abstract excerpt

Mouse adenovirus type 1 (MAV-1) early region 1A (E1A) viral mutants were used to determine the importance of this region in pathogenesis and establishment of a persistent infection in the natural host. Lethal dose analysis with adult male Swiss outbred mice revealed a significant reduction in virulence for all of the E1A mutants. During acute infections with 10(5) PFU of virus, an E1A null mutant, pmE109, was...

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Identifiers

PMID: 9621028
DOI: 10.1128/JVI.72.7.5699-5706.1998
PMCID: PMC110240

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