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Article

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

21 Jun 1994

Abstract excerpt

First-generation recombinant adenoviruses that lack E1 sequences have shown tremendous promise in animal and human models of gene therapy. Important limitations of these vectors are that recombinant gene expression is transient and inflammation occurs at the site of gene transfer. Our hypothesis for generating vectors with increased persistence is that present recombinant adenoviruses express viral proteins that...

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Identifiers

PMID: 8016137
DOI: 10.1073/pnas.91.13.6196

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Source receipt: pubmed, retrieved 7 Sept 2026.

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