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Article

Elimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell culture.

Journal of virology - 1 Jun 2005

Ghazal Peter, Visser Astrid E, Gustems Montse, García Rosalía, Borst Eva Maria, Sullivan Kevin, Messerle Martin, Angulo Ana

Abstract excerpt

The major immediate-early (MIE) genes of cytomegaloviruses (CMV) are broadly thought to be decisive regulators of lytic replication and reactivation from latency. To directly assess the role of the MIE protein IE1 during the infection of murine CMV (MCMV), we constructed an MCMV with exon 4 of the ie1 gene deleted. We found that, independent of the multiplicity of infection, the resulting recombinant virus,...

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Identifiers

PMID: 15890957
DOI: 10.1128/JVI.79.11.7182-7194.2005
PMCID: PMC1112098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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