Article
The hepatitis B virus seroconversion to anti-HBe is frequently associated with HBV genotype changes and selection of preS2-defective particles in chronically infected children.
Virology - 25 May 1998
Gerner P R, Friedt M, Oettinger R, Lausch E, Wirth S
Abstract excerpt
In order to investigate the generation and selection of hepatitis B virus mutants and the influence of interferon on their evolution, a longitudinal study including 22 patients was performed. The complete preS1/S2 open reading frame was analyzed by direct sequencing from serum samples obtained before and after seroconversion to anti-HBe in 11 children without alpha-interferon treatment. Furthermore, in 11 cases...
Topics
- Amino Acid Sequence
- Antibodies, Viral
- Antibody Specificity
- Child
- Child, Preschool
- Chronic Disease
- Genome, Viral
- Hepatitis B
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Humans
- Interferon-gamma
- Molecular Sequence Data
- Mutation