Article
Genomic variability in the preS1 region and determination of routes of transmission of hepatitis B virus.
The Journal of general virology - 1 Nov 1992
Uy A, Wunderlich G, Olsen D B, Heermann K H, Gerlich W H, Thomssen R
Abstract excerpt
On the basis of published sequence data the preS1 attachment region of hepatitis B virus (HBV) appears to be highly variable. Using a novel method for rapid DNA sequencing by the polymerase chain reaction we screened 34 HBV DNA-positive sera for mutations in a variable part of the preS1 region of the HBV genome. The sequence data were used to analyse potential chains of infection, and strongly supported the...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA, Viral
- Genes, Viral
- Genetic Variation
- Genome, Viral
- Hepatitis B
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Humans
- Molecular Sequence Data