Article
Binding of six chimeric analogs of omega-conotoxin MVIIA and MVIIC to N- and P/Q-type calcium channels.
Biochemical and biophysical research communications - 5 Mar 2000
Sato K, Raymond C, Martin-Moutot N, Sasaki T, Ohtake A, Minami K, Van Renterghem C, Takahashi M, Seagar M J
Abstract excerpt
Replacement of the N-terminal half of omega-conotoxin MVIIC, a peptide blocker of P/Q-type calcium channels, with that of omega-conotoxin MVIIA significantly increased the affinity for N-type calcium channels. To identify the residues essential for subtype selectivity, we examined single reverse mutations from MVIIA-type to MVIIC-type in this chimeric analog. A reverse mutation from Lys(7) to Pro(7) decreased the...
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