Article
Generation of polyclonal antibody against mu-conotoxin GIIIA using an immunogen of [Cys(5)]mu-conotoxin GIIIA site-specifically conjugated with bovine serum albumin.
Biochemical and biophysical research communications - 25 Jan 2002
Nakamura Mitsuhiro, Oba Yuichi, Mori Tatsuya, Sato Kazuki, Ishida Yukisato, Matsuda Tsukasa, Nakamura Hideshi
Abstract excerpt
mu-Conotoxin GIIIA, one of the strong peptide toxins in the cone shell, preferentially blocks the skeletal muscle-type sodium channels in vertebrates. The toxicity of mu-conotoxin GIIIA is nearly equal to that of tetrodotoxin. The generation of an antibody for the native toxins is analytically useful, but practically difficult due to its high toxicity to animals. In this study, we generated the polyclonal...
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