Article
Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease.
American journal of medical genetics - 28 Mar 1998
Kunugi H, Kawada Y, Hattori M, Ueki A, Otsuka M, Nanko S
Abstract excerpt
Tyrosine hydroxylase (TH) gene is the rate-limiting enzyme in the synthesis of catecholamines. Functional polymorphisms of the TH gene may be involved in the pathogenesis of neuropsychiatric diseases such as schizophrenia, affective disorders, and Parkinsonism. This study examined a possible association of two polymorphisms, both of which result in an amino acid change of the TH protein, with schizophrenia and...
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