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Article

Association study of human MTH1 Ile45Thr polymorphism with sporadic Parkinson's disease.

European neurology - 1 Jan 2008

Jiang Gaofeng, Xu Lei, Wang Lin, Song Shizhen, Zhu Changcai

Abstract excerpt

Human MTH1, an oxidized purine nucleoside triphosphatase, hydrolyzes 8-oxo-dGTP thereby preventing its misincorporation into DNA. The present study was designed to investigate a possible link between the MTH1 Ile45Thr polymorphism and the development of sporadic Parkinson disease (PD). This case-control study consisted of 106 PD patients and 135 unrelated controls. MTH1 polymorphism was detected by polymerase...

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PMID: 17917452
DOI: 10.1159/000109255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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