Article
Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism.
American journal of medical genetics - 7 Sept 1998
Ishiguro H, Arinami T, Saito T, Akazawa S, Enomoto M, Mitushio H, Fujishiro H, Tada K, Akimoto Y, Mifune H, Shiozuka S, Hamaguchi H, Toru M, Shibuya H
Abstract excerpt
Tyrosine hydroxylase is the rate-limiting step in the biosynthesis of catecholamines. To find variants in the tyrosine hydroxylase (TH) gene that are associated with schizophrenia, mood disorders, or alcohol dependence, all of the exons, the exon-intron boundaries, and the 5' promoter region of t...
Topics
- Adult
- Aged
- Alcoholism
- Base Sequence
- Chromosomes, Human, Pair 11
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genome, Human
- Humans
- Introns
- Male
- Middle Aged
- Molecular Sequence Data