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Article

Functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects IQ in schizophrenia.

Psychiatry and clinical neurosciences - 1 Jun 2014

Horiguchi Mieko, Ohi Kazutaka, Hashimoto Ryota, Hao Qinyu, Yasuda Yuka, Yamamori Hidenaga, Fujimoto Michiko, Umeda-Yano Satomi, Takeda Masatoshi, Ichinose Hiroshi

Abstract excerpt

AIMS: Progressive cognitive decline has been an important issue in the treatment and care of patients with schizophrenia. Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the biosynthesis of catecholamine, including dopamine and noradrenaline. In this report, we examined a possible association of a genetic variant in the TH promoter region. METHODS: Association of a genetic variant in the TH promoter...

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PMID: 24417771
DOI: 10.1111/pcn.12157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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