Article
Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells.
The Journal of biological chemistry - 27 Aug 2004
Lorch Jochen H, Klessner Jodi, Park J Ken, Getsios Spiro, Wu Yvonne L, Stack M Sharon, Green Kathleen J
Abstract excerpt
The epidermal growth factor receptor (EGFR) has been proposed as a key modulator of cadherin-containing intercellular junctions, particularly in tumors that overexpress this tyrosine kinase. Here the EGFR tyrosine kinase inhibitor PKI166 and EGFR blocking antibody C225, both of which are used clinically to treat head and neck cancers, were used to determine the effects of EGFR inhibition on intercellular junction...
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