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Article

Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding.

The Journal of biological chemistry - 5 Jun 1998

Ozer J, Mitsouras K, Zerby D, Carey M, Lieberman P M

Abstract excerpt

The interaction of the general transcription factor (TF) IIA with TFIID is required for transcription activation in vitro. TFIID consists of the TATA-binding protein (TBP) and TBP associated factors (TAFIIs). TFIIA binds directly to TBP and stabilizes its interaction with TATA-containing DNA. In this work, we present evidence that TAFIIs inhibit TBP-DNA and TBP-TFIIA binding, and that TFIIA stimulates...

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Source

Identifiers

PMID: 9603936
DOI: 10.1074/jbc.273.23.14293

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Transcription factor IIA derepresses TATA-binding protein (TBP)-associated factor inhibition of TBP-DNA binding.PMID 9603936Read ↗

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Requirement for transcription factor IIA (TFIIA)-TFIID recruitment by an activator depends on promoter structure and template competition.Semantic proximity Read ↗

Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation.Semantic proximity Read ↗

Distinct mutations in yeast TAF(II)25 differentially affect the composition of TFIID and SAGA complexes as well as global gene expression patterns.Semantic proximity Read ↗

A TATA-binding protein mutant defective for TFIID complex formation in vivo.Semantic proximity Read ↗

Analysis of TFIIA function In vivo: evidence for a role in TATA-binding protein recruitment and gene-specific activation.Semantic proximity Read ↗

TFIIA interacts with TFIID via association with TATA-binding protein and TAF40.Semantic proximity Read ↗

Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry.Semantic proximity Read ↗

Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II.Semantic proximity Read ↗

Role of the TATA binding protein-transcription factor IIB interaction in supporting basal and activated transcription in plant cells.Semantic proximity Read ↗

Association of transcription factor IIA with TATA binding protein is required for transcriptional activation of a subset of promoters and cell cycle progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

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