Article
Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase.
Journal of neurochemistry - 1 Jun 1998
Thomas S A, Marck B T, Palmiter R D, Matsumoto A M
Abstract excerpt
Mice with a targeted disruption of the dopamine beta-hydroxylase (DBH) gene are unable to synthesize norepinephrine (NE) and epinephrine. These mice have elevated levels of dopamine in most tissues, although the levels are only a fraction of those normally found for NE. It is noteworthy that NE c...
Topics
- Animals
- Brain
- Carrier Proteins
- Dopamine
- Dopamine beta-Hydroxylase
- Dose-Response Relationship, Drug
- Droxidopa
- Epinephrine
- Hindlimb
- Ion Channels
- Male
- Membrane Proteins
- Mice