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Article

Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic.

Cell - 29 Dec 1995

Zhou Q Y, Palmiter R D

Abstract excerpt

Mice unable to synthesize dopamine (DA) specifically in dopaminergic neurons were created by inactivating the tyrosine hydroxylase (TH) gene then by restoring TH function in noradrenergic cells. These DA-deficient (DA-/-) mice were born at expected frequency but became hypoactive and stopped feeding a few weeks after birth. Midbrain dopaminergic neurons, their projections, and most characteristics of their target...

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Identifiers

PMID: 8548806
DOI: 10.1016/0092-8674(95)90145-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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