Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic.

doi:10.1016/0092-8674(95)90145-0

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Article

Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic.

Cell - 29 Dec 1995

Zhou Q Y, Palmiter R D

Abstract excerpt

Mice unable to synthesize dopamine (DA) specifically in dopaminergic neurons were created by inactivating the tyrosine hydroxylase (TH) gene then by restoring TH function in noradrenergic cells. These DA-deficient (DA-/-) mice were born at expected frequency but became hypoactive and stopped feed...

Topics

Adrenergic Fibers
Animals
Animals, Newborn
Behavior, Animal
Dopamine
Dopamine beta-Hydroxylase
Drinking Behavior
Dynorphins
Embryo, Mammalian
Feeding Behavior
Immunohistochemistry
In Situ Hybridization
Levodopa
Mesencephalon
Mice
Mice, Transgenic
Mutation
Neostriatum

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