Article
Glucocorticoid-dependent action of neural crest factor AP-2: stimulation of phenylethanolamine N-methyltransferase gene expression.
Journal of neurochemistry - 1 Jun 1998
Ebert S N, Ficklin M B, Her S, Siddall B J, Bell R A, Ganguly K, Morita K, Wong D L
Abstract excerpt
AP-2 is a vertebrate transcription factor expressed in neural crest cells and their derivative tissues, including the adrenal medulla, where epinephrine is produced. AP-2 is shown to stimulate expression of the gene encoding the epinephrine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT). However, stimulation of the PNMT gene by AP-2 requires glucocorticoids and appears to be mediated through...
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