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Article

Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland.

Journal of molecular endocrinology - 1 Jun 2011

Gorrigan Rebecca J, Guasti Leonardo, King Peter, Clark Adrian J, Chan Li F

Abstract excerpt

The melanocortin-2-receptor (MC2R)/MC2R accessory protein (MRAP) complex is critical to the production of glucocorticoids from the adrenal cortex. Inactivating mutations in either MC2R or MRAP result in the clinical condition familial glucocorticoid deficiency. The localisation of MC2R together with MRAP within the adrenal gland has not previously been reported. Furthermore, MRAP2, a paralogue of MRAP, has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21367968
DOI: 10.1530/JME-11-0011
PMCID: PMC3111094

Genes

MRAP
MRAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland.PMID 21367968Read ↗

Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane.Semantic proximity Read ↗

Familial glucocorticoid deficiency: advances in the molecular understanding of ACTH action.Semantic proximity Read ↗

Pathophysiology of melanocortin receptors and their accessory proteins.Semantic proximity Read ↗

Differential Regulation of the Human Adrenocorticotropin Receptor [Melanocortin-2 Receptor (MC2R)] by Human MC2R Accessory Protein Isoforms α and β in Isogenic Human Embryonic Kidney 293 CellsSemantic proximity Read ↗

Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2.Semantic proximity Read ↗

Clinical and biological phenotype of a patient with familial glucocorticoid deficiency type 2 caused by a mutation of melanocortin 2 receptor accessory protein.Semantic proximity Read ↗

Missense Mutations in the Melanocortin 2 Receptor Accessory Protein That Lead to Late Onset Familial Glucocorticoid Deficiency Type 2Semantic proximity Read ↗

Melanocortin 4 Receptor Becomes an ACTH Receptor by Coexpression of Melanocortin Receptor Accessory Protein 2Semantic proximity Read ↗

The Majority of Adrenocorticotropin Receptor (Melanocortin 2 Receptor) Mutations Found in Familial Glucocorticoid Deficiency Type 1 Lead to Defective Trafficking of the Receptor to the Cell SurfaceSemantic proximity Read ↗

The genetics of ACTH resistance syndromes.Semantic proximity Read ↗

Loss of the C terminus of melanocortin receptor 2 (MC2R) results in impaired cell surface expression and ACTH insensitivity.Semantic proximity Read ↗

Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiologySemantic proximity Read ↗

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