Article
Glucocorticoids activate somatostatin gene transcription through co-operative interaction with the cyclic AMP signalling pathway.
The Biochemical journal - 1 Aug 1994
Liu J L, Papachristou D N, Patel Y C
Abstract excerpt
The somatostatin (SS) gene is transcriptionally regulated via the cyclic AMP (cAMP) response element (CRE), located in the proximal promoter (-41 to -48 bp). We have previously reported that glucocorticoids induce dose-dependent cell-specific alterations in the steady-state SS mRNA level. Here we...
Topics
- Animals
- Base Sequence
- Chloramphenicol O-Acetyltransferase
- Colforsin
- Cyclic AMP
- Cyclic AMP Response Element-Binding Protein
- Cyclic AMP-Dependent Protein Kinases
- DNA
- Dexamethasone
- Drug Synergism
- Gene Expression Regulation
- Mutation
- Pheochromocytoma
- Promoter Regions, Genetic
- Rats
- Recombinant Fusion Proteins
- Signal Transduction
- Somatostatin