Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucocorticoids activate somatostatin gene transcription through co-operative interaction with the cyclic AMP signalling pathway.

The Biochemical journal - 1 Aug 1994

Liu J L, Papachristou D N, Patel Y C

Abstract excerpt

The somatostatin (SS) gene is transcriptionally regulated via the cyclic AMP (cAMP) response element (CRE), located in the proximal promoter (-41 to -48 bp). We have previously reported that glucocorticoids induce dose-dependent cell-specific alterations in the steady-state SS mRNA level. Here we have investigated direct transcriptional control of the SS gene by glucocorticoids. We have examined transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Promoter Regions, Genetic

Share to Recombinant Fusion Proteins

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 7914402
DOI: 10.1042/bj3010863
PMCID: PMC1137066

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoids activate somatostatin gene transcription through co-operative interaction with the cyclic AMP signalling pathway.PMID 7914402Read ↗

Glucocorticoid Regulation of Bone Sialoprotein (BSP) Gene ExpressionSemantic proximity Read ↗

A composite hormone response element regulates transcription of the rat GHRH receptor gene.Semantic proximity Read ↗

Glucocorticoid activation of the neuronal nicotinic acetylcholine receptor alpha7 subunit gene: involvement of transcription factor Egr-1.Semantic proximity Read ↗

The glucocorticoid receptor regulates the binding of C/EPBbeta on the alpha-1-acid glycoprotein promoter in vivo.Semantic proximity Read ↗

Effects of mutation of the CREB binding site of the somatostatin promoter on cyclic AMP responsiveness in CV-1 cells.Semantic proximity Read ↗

Identification of cis-elements mediating the stimulation of rat insulin-like growth factor-binding protein-1 promoter activity by dexamethasone, cyclic adenosine 3',5'-monophosphate, and phorbol esters, and inhibition by insulin.Semantic proximity Read ↗

Glucocorticoid receptor binding site in the mouse alpha-amylase 2 gene mediates response to the hormone.Semantic proximity Read ↗

Three steroidogenic factor-1 binding elements are required for constitutive and cAMP-regulated expression of the human adrenocorticotropin receptor gene.Semantic proximity Read ↗

Mutually dependent response elements in the cis-regulatory region of the neurotensin/neuromedin N gene integrate environmental stimuli in PC12 cells.Semantic proximity Read ↗

The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism.Semantic proximity Read ↗

The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers.Semantic proximity Read ↗

Glucocorticoid-dependent action of neural crest factor AP-2: stimulation of phenylethanolamine N-methyltransferase gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.