Article
Transcription factor AP-2β regulates the neurotransmitter phenotype and maturation of chromaffin cells.
Molecular and cellular neurosciences - 1 Jan 2011
Hong Seok Jong, Huh Yang Hoon, Leung Amanda, Choi Hyun Jin, Ding Yunmin, Kang Un Jung, Yoo Seung Hyun, Buettner Reinhard, Kim Kwang-Soo
Abstract excerpt
During development, sympathetic neurons and chromaffin cells originate from bipotential sympathoadrenal (SA) progenitors arising from neural crests (NC) in the trunk regions. Recently, we showed that AP-2β, a member of the AP2 family, plays a critical role in the development of sympathetic neurons and locus coeruleus and their norepinephrine (NE) neurotransmitter phenotype. In the present study, we investigated...
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