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Article

Normal colonic mucosa in hereditary non-polyposis colorectal cancer shows no generalised increase in somatic mutation.

British journal of cancer - 1 May 1995

Williams G T, Geraghty J M, Campbell F, Appleton M A, Williams E D

Abstract excerpt

Hereditary non-polyposis colorectal cancer (HNPCC) has recently been linked to germline defects of DNA repair genes. Colorectal tumours in HNPCC frequently show DNA microsatellite instability, but it is not certain whether this mutator phenotype occurs throughout the morphologically normal colonic mucosa. We have previously used the mPAS histochemical technique in human colorectal mucosa to identify a...

Topics

Adult
Aged
Aged, 80 and over
Colon
Colorectal Neoplasms, Hereditary Nonpolyposis
Crohn Disease
Female
Humans
Intestinal Mucosa
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Periodic Acid-Schiff Reaction

Phenotype

Source

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Identifiers

PMID: 7734304
DOI: 10.1038/bjc.1995.208
PMCID: PMC2033807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7734304-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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