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Article

Normal colonic mucosa in hereditary non-polyposis colorectal cancer shows no generalised increase in somatic mutation.

British journal of cancer - 1 May 1995

Williams G T, Geraghty J M, Campbell F, Appleton M A, Williams E D

Abstract excerpt

Hereditary non-polyposis colorectal cancer (HNPCC) has recently been linked to germline defects of DNA repair genes. Colorectal tumours in HNPCC frequently show DNA microsatellite instability, but it is not certain whether this mutator phenotype occurs throughout the morphologically normal colonic mucosa. We have previously used the mPAS histochemical technique in human colorectal mucosa to identify a...

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Identifiers

PMID: 7734304
DOI: 10.1038/bjc.1995.208
PMCID: PMC2033807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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