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Article

Improved envelope function selected by long-term cultivation of a translation-impaired HIV-1 mutant.

Virology - 10 May 1998

Das A T, van Dam A P, Klaver B, Berkhout B

Abstract excerpt

The untranslated leader region of the human immunodeficiency virus (HIV) RNA genome contains multiple regulatory elements that fold into stable hairpin structures. Because extensive secondary structure can block the scanning of ribosomes, an alternative mechanism for HIV translation seems feasible. To study the mechanism of HIV-1 mRNA translation, a start codon was introduced in the leader region that will usurp...

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Identifiers

PMID: 9601523
DOI: 10.1006/viro.1998.9124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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