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Article

Repair of a Rev-minus human immunodeficiency virus type 1 mutant by activation of a cryptic splice site.

Journal of virology - 1 Apr 2001

Verhoef K, Bilodeau P S, van Wamel J L, Kjems J, Stoltzfus C M, Berkhout B

Abstract excerpt

We isolated a revertant virus after prolonged culturing of a replication-impaired human immunodeficiency virus type 1 (HIV-1) mutant of which the Rev open reading frame was inactivated by mutation of the AUG translation initiation codon. Sequencing of the tat-rev region of this revertant virus identified a second-site mutation in tat that restored virus replication in the mutant background. This mutation...

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Identifiers

PMID: 11238879
DOI: 10.1128/JVI.75.7.3495-3500.2001
PMCID: PMC114146

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Source receipt: pubmed, retrieved 7 Sept 2026.

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