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Article

Quantitative differences in the distribution of zidovudine resistance mutations in multiple post-mortem tissues from AIDS patients.

Journal of medical virology - 1 Jun 1998

Atkins M, Strappe P, Kaye S, Loveday C, McLaughlin J E, Johnson M A, Tedder R S, Griffiths P D, Emery V C

Abstract excerpt

Replication of HIV introduces errors into the genome which are responsible for conferring a growth advantage over wildtype virus when drugs such as zidovudine (ZDV) exert a selective pressure. The molecular basis for HIV-1 resistance to ZDV has been mapped to codons 41, 67, 70, 215 and 219 of the...

Topics

Acquired Immunodeficiency Syndrome
Adult
Anti-HIV Agents
DNA Mutational Analysis
DNA, Viral
Drug Resistance, Microbial
Female
HIV-1
Humans
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proviruses

Reverse Transcriptase Inhibitors

Viral Load

Zidovudine

Source

Identifiers

PMID: 9598935
DOI: 10.1002/(sici)1096-9071(199806)55:2<138::aid-jmv10>3.0.co;2-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9598935-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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