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Article

Quantitative differences in the distribution of zidovudine resistance mutations in multiple post-mortem tissues from AIDS patients.

Journal of medical virology - 1 Jun 1998

Atkins M, Strappe P, Kaye S, Loveday C, McLaughlin J E, Johnson M A, Tedder R S, Griffiths P D, Emery V C

Abstract excerpt

Replication of HIV introduces errors into the genome which are responsible for conferring a growth advantage over wildtype virus when drugs such as zidovudine (ZDV) exert a selective pressure. The molecular basis for HIV-1 resistance to ZDV has been mapped to codons 41, 67, 70, 215 and 219 of the reverse transcriptase gene both in vitro and in clinical samples of blood. This study has investigated the...

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Source

Identifiers

PMID: 9598935
DOI: 10.1002/(sici)1096-9071(199806)55:2<138::aid-jmv10>3.0.co;2-e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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