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Article

Detection of drug resistance mutations in the human immunodeficiency virus type 1 (HIV-1) pol gene: differences in semen and blood HIV-1 RNA and proviral DNA.

The Journal of infectious diseases - 1 Nov 1994

Kroodsma K L, Kozal M J, Hamed K A, Winters M A, Merigan T C

Abstract excerpt

Different tissues or body fluids in which human immunodeficiency virus type 1 (HIV-1) can reside may contain viruses with distinct characteristics. Sixteen HIV-1-infected patients receiving zidovudine or didanosine were studied cross-sectionally and 1 patient who switched from zidovudine to didanosine was followed sequentially to determine if drug resistance mutations within the HIV-1 pol gene at codons 74 and...

Topics

Cross-Sectional Studies
DNA, Viral
Drug Resistance
Genes, Viral
Genes, pol
HIV-1
Humans
Male
Mutation
Proviruses
RNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Semen

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Identifiers

PMID: 7963730
DOI: 10.1093/infdis/170.5.1292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7963730-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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