Article
LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.
Infection and immunity - 1 Jun 1998
Sarker M R, Sory M P, Boyd A P, Iriarte M, Cornelis G R
Abstract excerpt
Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus requ...
Topics
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Bacterial Toxins
- Biological Transport
- Cytotoxins
- Eukaryotic Cells
- HeLa Cells
- Humans
- Macrophages
- Mutation
- Pore Forming Cytotoxic Proteins
- Protein Tyrosine Phosphatases
- Yersinia enterocolitica