Article
Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica.
Journal of bacteriology - 1 Aug 2001
DeBord K L, Lee V T, Schneewind O
Abstract excerpt
Yersinia enterocolitica target effector Yop proteins into the cytosol of eukaryotic cells by a mechanism requiring the type III machinery. LcrG and LcrV have been suggested to fulfill essential functions during the type III targeting of effector Yops. It is reported here that knockout mutations of lcrG caused mutant yersiniae to prematurely secrete Yops into the extracellular medium without abolishing the type...
Topics
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Calcium
- Cytoplasm
- HeLa Cells
- Humans
- Membrane Proteins
- Mutagenesis
- Phenotype
- Pore Forming Cytotoxic Proteins