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Article

Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica.

Journal of bacteriology - 1 Aug 2001

DeBord K L, Lee V T, Schneewind O

Abstract excerpt

Yersinia enterocolitica target effector Yop proteins into the cytosol of eukaryotic cells by a mechanism requiring the type III machinery. LcrG and LcrV have been suggested to fulfill essential functions during the type III targeting of effector Yops. It is reported here that knockout mutations of lcrG caused mutant yersiniae to prematurely secrete Yops into the extracellular medium without abolishing the type...

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Identifiers

PMID: 11443094
DOI: 10.1128/JB.183.15.4588-4598.2001
PMCID: PMC95354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica.PMID 11443094Read ↗

LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis.Semantic proximity Read ↗

LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.Semantic proximity Read ↗

The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG.Semantic proximity Read ↗

Diminished LcrV secretion attenuates Yersinia pseudotuberculosis virulence.Semantic proximity Read ↗

Interaction of the Yersinia pestis type III regulatory proteins LcrG and LcrV occurs at a hydrophobic interface.Semantic proximity Read ↗

The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation.Semantic proximity Read ↗

YscP and YscU regulate substrate specificity of the Yersinia type III secretion system.Semantic proximity Read ↗

The type III secretion chaperone LcrH co-operates with YopD to establish a negative, regulatory loop for control of Yop synthesis in Yersinia pseudotuberculosis.Semantic proximity Read ↗

Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis.Semantic proximity Read ↗

A chromosomally encoded type III secretion pathway in Yersinia enterocolitica is important in virulence.Semantic proximity Read ↗

YopD self-assembly and binding to LcrV facilitate type III secretion activity by Yersinia pseudotuberculosis.Semantic proximity Read ↗

LcrV mutants that abolish Yersinia type III injectisome function.Semantic proximity Read ↗

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