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Article

LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis.

Journal of bacteriology - 1 Sept 2001

Matson J S, Nilles M L

Abstract excerpt

Yersinia pestis expresses a set of plasmid-encoded virulence proteins called Yops and LcrV that are secreted and translocated into eukaryotic cells by a type III secretion system. LcrV is a multifunctional protein with antihost and positive regulatory effects on Yops secretion that forms a stable complex with a negative regulatory protein, LcrG. LcrG has been proposed to block the secretion apparatus (Ysc) from...

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Identifiers

PMID: 11489861
DOI: 10.1128/JB.183.17.5082-5091.2001
PMCID: PMC95384

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LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis.PMID 11489861Read ↗

Interaction of the Yersinia pestis type III regulatory proteins LcrG and LcrV occurs at a hydrophobic interface.Semantic proximity Read ↗

Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis.Semantic proximity Read ↗

The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG.Semantic proximity Read ↗

Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica.Semantic proximity Read ↗

Diminished LcrV secretion attenuates Yersinia pseudotuberculosis virulence.Semantic proximity Read ↗

YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops.Semantic proximity Read ↗

YscP of Yersinia pestis is a secreted component of the Yop secretion system.Semantic proximity Read ↗

The type III secretion chaperone LcrH co-operates with YopD to establish a negative, regulatory loop for control of Yop synthesis in Yersinia pseudotuberculosis.Semantic proximity Read ↗

LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.Semantic proximity Read ↗

The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation.Semantic proximity Read ↗

YopD self-assembly and binding to LcrV facilitate type III secretion activity by Yersinia pseudotuberculosis.Semantic proximity Read ↗

Mutations in yscC, yscD, and yscG prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis.Semantic proximity Read ↗

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