Article
YopD self-assembly and binding to LcrV facilitate type III secretion activity by Yersinia pseudotuberculosis.
The Journal of biological chemistry - 13 Aug 2010
Costa Tiago R D, Edqvist Petra J, Bröms Jeanette E, Ahlund Monika K, Forsberg Ake, Francis Matthew S
Abstract excerpt
YopD-like translocator proteins encoded by several Gram-negative bacteria are important for type III secretion-dependent delivery of anti-host effectors into eukaryotic cells. This probably depends on their ability to form pores in the infected cell plasma membrane, through which effectors may gain access to the cell interior. In addition, Yersinia YopD is a negative regulator essential for the control of...
Topics
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation
- Pore Forming Cytotoxic Proteins
- Protein Binding
- Protein Multimerization
- Protein Structure, Tertiary
- Structure-Activity Relationship
- Yersinia pseudotuberculosis