The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG.

doi:10.1128/JB.180.13.3410-3420.1998

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Article

The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG.

Journal of bacteriology - 1 Jul 1998

Nilles M L, Fields K A, Straley S C

Abstract excerpt

Yersinia pestis expresses a set of secreted proteins called Yops and the bifunctional LcrV, which has both regulatory and antihost functions. Yops and LcrV expression and the activity of the type III mechanism for their secretion are coordinately regulated by environmental signals such as Ca2+ co...

Topics

Antigens, Bacterial
Bacterial Outer Membrane Proteins
Bacterial Proteins
Calcium
Cell Survival
DNA Primers
Escherichia coli
Genetic Vectors
HeLa Cells
Hemolysis
Humans
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Polymerase Chain Reaction

Pore Forming Cytotoxic Proteins

Recombinant Proteins

Signal Transduction

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 9642196
DOI: 10.1128/JB.180.13.3410-3420.1998
PMCID: PMC107298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9642196-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG.PMID 9642196Read ↗

LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis.Semantic proximity Read ↗

Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis.Semantic proximity Read ↗

YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops.Semantic proximity Read ↗

lcrR, a low-Ca2(+)-response locus with dual Ca2(+)-dependent functions in Yersinia pestis.Semantic proximity Read ↗

The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation.Semantic proximity Read ↗

YscB of Yersinia pestis functions as a specific chaperone for YopN.Semantic proximity Read ↗

Interaction of the Yersinia pestis type III regulatory proteins LcrG and LcrV occurs at a hydrophobic interface.Semantic proximity Read ↗

YscP of Yersinia pestis is a secreted component of the Yop secretion system.Semantic proximity Read ↗

Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica.Semantic proximity Read ↗

Hijacking of the pleiotropic cytokine interferon-γ by the type III secretion system of Yersinia pestis.Semantic proximity Read ↗

Diminished LcrV secretion attenuates Yersinia pseudotuberculosis virulence.Semantic proximity Read ↗

Autoproteolysis of YscU of Yersinia pseudotuberculosis is important for regulation of expression and secretion of Yop proteins.Semantic proximity Read ↗

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