Analysis of host cells associated with the Spv-mediated increased intracellular growth rate of Salmonella typhimurium in mice.

doi:10.1128/IAI.66.6.2471-2485.1998

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Article

Analysis of host cells associated with the Spv-mediated increased intracellular growth rate of Salmonella typhimurium in mice.

Infection and immunity - 1 Jun 1998

Gulig P A, Doyle T J, Hughes J A, Matsui H

Abstract excerpt

The 90-kb virulence plasmid of Salmonella typhimurium encodes five spv genes which increase the growth rate of the bacteria within host cells within the first week of systemic infection of mice (P. A. Gulig and T. J. Doyle, Infect. Immun. 61:504-511, 1993). The presently described study was aimed at identifying the host cells associated with Spv-mediated virulence by manipulating the mouse host and the...

Topics

Agranulocytosis
Animals
Bacterial Proteins
Cyclophosphamide
Lymphocytes
Macrophages
Mice
Mice, Inbred BALB C
Mice, Mutant Strains
Mice, Nude
Mice, SCID
Neutrophils

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Salmonella Infections, Animal

Salmonella typhimurium

Spleen

Virulence

Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 9596705
DOI: 10.1128/IAI.66.6.2471-2485.1998
PMCID: PMC108227

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