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Article

The Salmonella virulence plasmid spv genes are required for cytopathology in human monocyte-derived macrophages.

Cellular microbiology - 1 Feb 2000

Libby S J, Lesnick M, Hasegawa P, Weidenhammer E, Guiney D G

Abstract excerpt

The pathogenesis of serious systemic Salmonella infections is characterized by survival and proliferation of bacteria inside macrophages. Infection of human monocyte-derived macrophages in vitro with S. typhimurium or S. dublin produces cytopathology characterized by detachment of cells that contain large numbers of proliferating bacteria. This cytopathology is dependent on the expression of the bacterial spv...

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PMID: 11207562
DOI: 10.1046/j.1462-5822.2000.00030.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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