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Article

Identification, genetic analysis and DNA sequence of a 7.8-kb virulence region of the Salmonella typhimurium virulence plasmid.

Molecular microbiology - 1 May 1992

Gulig P A, Caldwell A L, Chiodo V A

Abstract excerpt

The 90-kilobase (kb) virulence plasmid of Salmonella typhimurium is responsible for invasion from the intestines to mesenteric lymph nodes and spleens of orally inoculated mice. We used Tn5 and aminoglycoside phosphotransferase (aph) gene insertion mutagenesis and deletion mutagenesis of a previously identified 14-kb virulence region to reduce this virulence region to 7.8kb. The 7.8-kb virulence region subcloned...

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PMID: 1322485
DOI: 10.1111/j.1365-2958.1992.tb00860.x

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