Article
Characterization of the mitochondrial DNA abnormalities in the skeletal muscle of patients with inclusion body myositis.
Journal of neuropathology and experimental neurology - 1 May 1998
Horvath R, Fu K, Johns T, Genge A, Karpati G, Shoubridge E A
Abstract excerpt
Inclusion body myositis (IBM) is a late-onset inflammatory myopathy with distinctive clinical and histopathological features. The molecular basis for the disease remains unknown, but abnormal nuclear morphology and the accumulation of a protein that binds single-stranded DNA in a sequence-independent fashion suggest a nuclear defect. Evidence of mitochondrial respiratory chain dysfunction (ragged-red fibers,...
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