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Article

Analysis of multiple mitochondrial DNA deletions in inclusion body myositis

1 Jan 1997

Abstract excerpt

Inclusion body myositis (IBM) is a sporadic progressive myopathy, which is morphologically characterized by inflammatory cell infiltrates and rimmed vacuoles in muscle fibers. Mitochondrial changes are regularly present with ragged-red fibers showing deficiency of cytochrome c oxidase. In these muscle fiber segments, there is accumulation of mitochondria with mitochondrial DNA (mtDNA) deletions. There are...

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PMID: 9375854
DOI: 10.1002/(sici)1098-1004(1997)10:5<381::aid-humu8>3.0.co;2-i

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