Article
Mitochondrial abnormalities in inclusion-body myositis.
Neurology - 24 Jan 2006
Oldfors A, Moslemi A R, Jonasson L, Ohlsson M, Kollberg G, Lindberg C
Abstract excerpt
Mitochondrial changes are frequently encountered in sporadic inclusion-body myositis (s-IBM). Cytochrome c oxidase (COX)-deficient muscle fibers and large-scale mitochondrial DNA (mtDNA) deletions are more frequent in s-IBM than in age-matched controls. COX deficient muscle fibers are due to clonal expansion of mtDNA deletions and point mutations in segments of muscle fibers. Such segments range from 75 microm to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.