Glycosylation of Asn-632 and Asn-651 is important for functional expression of endothelin-converting enzyme-1.

doi:10.1097/00005344-199800001-00003

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Article

Glycosylation of Asn-632 and Asn-651 is important for functional expression of endothelin-converting enzyme-1.

Journal of cardiovascular pharmacology - 1 Jan 1998

Nelboeck P, Fuchs M, Bur D, Löffler B M

Abstract excerpt

It has been shown previously that N-glycosylation of Asn-144 and/or Asn-627 is important for functional expression of neutral endopeptidase-24.11 (NEP). All glycosylation sites of NEP are conserved within endothelin-converting enzyme-1 (ECE-1). In the present study we investigated the importance...

Topics

Animals
Asparagine
Aspartic Acid Endopeptidases
Blotting, Western
CHO Cells
Cricetinae
Endothelin-Converting Enzymes
Glycosylation
Metalloendopeptidases
Mutation
Protein Biosynthesis

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