Article
Effects of mutating different steroidogenic factor-1 protein regions on gene regulation.
Endocrine - 1 Apr 2001
Lopez D, Nackley A C, Shea-Eaton W, Xue J, Schimmer B P, McLean M P
Abstract excerpt
The involvement of cyclic adenosine monophosphate cAMP-dependent protein kinase A (PKA) in the regulation of the steroidogenic acute regulatory protein (StAR) and the high-density lipoprotein receptor (HDL-R) genes by steroidogenic factor-1 (SF-1) and cAMP were examined. Cotransfection studies carried out in Kin 8 cells, a Y1 cell line (mouse adrenal) with a mutation in the type I PKA regulatory subunit,...
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