Article
Sex-specific effects of an insulin secretagogue in stroke-prone hypertensive rats.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 1993
Peuler J D, Johnson B A, Phare S M, Sowers J R
Abstract excerpt
Glyburide, an insulin secretagogue and an insulin-sensitizing agent, lowers blood pressure in normal male and female dogs when administered acutely. Because insulin resistance may contribute to spontaneous hypertension in rats, we sought to determine if long-term administration of glyburide (5 mg/kg per day by diet, age 5 weeks to 5 months) would lower blood pressure in male and female stroke-prone spontaneously...
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