Article
Comparative effects of paclitaxel and rapamycin on smooth muscle migration and survival: role of AKT-dependent signaling.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2006
Patterson Cam, Mapera Sabeen, Li Hui-Hua, Madamanchi Nageswara, Hilliard Eleanor, Lineberger Rob, Herrmann Robert, Charles Peter
Abstract excerpt
OBJECTIVE: Advances in stent technology have enabled the delivery of drugs to improve outcomes after stent deployment. However, the optimal payloads for stents are not clear, and the appropriate stent-based therapies for high-risk patients, such as diabetics, have not been clearly established. METHODS AND RESULTS: We used smooth muscle cell culture models to compare the activities of rapamycin and paclitaxel....
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