Article
Paradoxical expression of adenosine deaminase in T cells cultured from a patient with adenosine deaminase deficiency and combine immunodeficiency.
The Journal of clinical investigation - 1 Aug 1990
Arredondo-Vega F X, Kurtzberg J, Chaffee S, Santisteban I, Reisner E, Povey M S, Hershfield M S
Abstract excerpt
T lymphocytes cultured from a patient (T.D.) with adenosine deaminase (ADA) deficiency expressed ADA activity in the normal range, inconsistent with her severe immunodeficiency, metabolic abnormalities, and with the absence of ADA activity in her B lymphocytes and other nucleated hematopoietic ce...
Topics
- Adenosine Deaminase
- Antigens, CD
- Blotting, Northern
- Blotting, Southern
- Cells, Cultured
- Gene Expression
- Hematopoietic Stem Cells
- Immunologic Deficiency Syndromes
- Interleukin-2
- Mutation
- Nucleoside Deaminases
- Oligonucleotide Probes
- Polymerase Chain Reaction