Article
Immortalized human pituitary cells express glycoprotein alpha-subunit and thyrotropin beta (TSH beta).
The Journal of clinical endocrinology and metabolism - 1 May 1998
Ham J, Webster J, Bond J A, Jasani B, Lewis M D, Hepburn P J, Davies J S, Lewis B M, Thomas D W, Scanlon M F
Abstract excerpt
A major problem in the study of human pituitary cells is their lack of proliferative capacity in vitro. To address this issue, we have infected normal human, postmortem pituitary cells in monolayer culture with a temperature-sensitive (tsA58) mutant of SV40 large T antigen. Several epithelial-lik...
Topics
- Antigens, Polyomavirus Transforming
- Cell Division
- Cell Line, Transformed
- Epithelial Cells
- Gene Expression
- Glycoprotein Hormones, alpha Subunit
- Humans
- Immunohistochemistry
- Karyotyping
- Keratins
- Mutation