Article
HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Feb 1998
Valevski A, Klein T, Gazit E, Meged S, Stein D, Elizur A, Narinsky E R, Kutzuk D, Weizman A
Abstract excerpt
To further substantiate reports of an association between the major histocompatibility complex subtypes and clozapine-induced agranulocytosis, HLA typing was performed in 61 Jewish Israeli schizophrenic patients, in 11 of whom agranulocytosis developed following clozapine treatment and in 50 (con...
Topics
- Adult
- Agranulocytosis
- Antipsychotic Agents
- Clozapine
- Female
- Genes, MHC Class I
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-B Antigens
- HLA-B38 Antigen
- Haplotypes
- Histocompatibility Testing
- Humans
- Israel
- Jews
- Male
- Middle Aged
- Schizophrenia