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Article

Human leukocyte antigen typing, response to neuroleptics, and clozapine-induced agranulocytosis in jewish Israeli schizophrenic patients.

International clinical psychopharmacology - 1 Sept 1999

Meged S, Stein D, Sitrota P, Melamed Y, Elizur A, Shmuelian I, Gazit E

Abstract excerpt

The atypical antipsychotic agent clozapine is known to be effective in schizophrenic patients refractory to other medications; however, it induces agranulocytosis in approximately 1-2%. In Jews, this complication is associated with the haplotype HLA B38,DR4,DQ3. The aim of the present study was to determine which human leukocyte antigen (HLA) antigens are involved in clozapine-induced agranulocytosis. We...

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PMID: 10529073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Human leukocyte antigen typing, response to neuroleptics, and clozapine-induced agranulocytosis in jewish Israeli schizophrenic patients.PMID 10529073Read ↗

HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients.Semantic proximity Read ↗

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HLA associations in clozapine-induced agranulocytosis.Semantic proximity Read ↗

Mitchell B. Balter Award. Human leukocyte antigen-A1 predicts a good therapeutic response to clozapine with a low risk of agranulocytosis in patients with schizophrenia.Semantic proximity Read ↗

The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups.Semantic proximity Read ↗

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and AgranulocytosisSemantic proximity Read ↗

Clozapine-induced agranulocytosis and its genetic determinants.Semantic proximity Read ↗

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Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Semantic proximity Read ↗

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