Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HSP70-2 9.0 kb variant is in linkage disequilibrium with the HLA-B and DRB1* alleles associated with clozapine-induced agranulocytosis.

The Journal of clinical psychiatry - 1 Sept 1994

Corzo D, Yunis J J, Yunis E J, Howard A, Lieberman J A

Abstract excerpt

In order to extend the analysis of the association between class I and class II HLA markers and HSP-70 alleles, we studied the genetic polymorphism of HSP70-2 genes by restriction fragment length polymorphism analysis in a panel of HLA-homozygous cell lines carrying the HLA-B alleles known to be associated with clozapine-induced agranulocytosis. We have found a linkage disequilibrium between the 9.0 kb variant of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clozapine
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-B Antigens

Share to HLA-DR2 Antigen

Share to HLA-DR4 Antigen

Share to HSP70 Heat-Shock Proteins

Share to Linkage Disequilibrium

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 7961560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HSP70-2 9.0 kb variant is in linkage disequilibrium with the HLA-B and DRB1* alleles associated with clozapine-induced agranulocytosis.PMID 7961560Read ↗

The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups.Semantic proximity Read ↗

HLA associations in clozapine-induced agranulocytosis.Semantic proximity Read ↗

Clozapine-induced agranulocytosis in schizophrenic Caucasians: confirming clues for associations with human leukocyte class I and II antigens.Semantic proximity Read ↗

HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients.Semantic proximity Read ↗

HLA-B38, DR4, DQw3 and Clozapine-Induced Agranulocytosis in Jewish Patients With SchizophreniaSemantic proximity Read ↗

Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry.Semantic proximity Read ↗

Clozapine rechallenge after excluding the high-risk clozapine-induced agranulocytosis genotype of HLA-DQB1 6672G>C.Semantic proximity Read ↗

Mitchell B. Balter Award. Human leukocyte antigen-A1 predicts a good therapeutic response to clozapine with a low risk of agranulocytosis in patients with schizophrenia.Semantic proximity Read ↗

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Semantic proximity Read ↗

Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis.Semantic proximity Read ↗

Human leukocyte antigen typing, response to neuroleptics, and clozapine-induced agranulocytosis in jewish Israeli schizophrenic patients.Semantic proximity Read ↗

Clozapine-induced agranulocytosis and its genetic determinants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.