Article
HSP70-2 9.0 kb variant is in linkage disequilibrium with the HLA-B and DRB1* alleles associated with clozapine-induced agranulocytosis.
The Journal of clinical psychiatry - 1 Sept 1994
Corzo D, Yunis J J, Yunis E J, Howard A, Lieberman J A
Abstract excerpt
In order to extend the analysis of the association between class I and class II HLA markers and HSP-70 alleles, we studied the genetic polymorphism of HSP70-2 genes by restriction fragment length polymorphism analysis in a panel of HLA-homozygous cell lines carrying the HLA-B alleles known to be...
Topics
- Agranulocytosis
- Clozapine
- Genetic Variation
- HLA-B Antigens
- HLA-DR2 Antigen
- HLA-DR4 Antigen
- HSP70 Heat-Shock Proteins
- Humans
- Linkage Disequilibrium
- Polymorphism, Genetic