Article
Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.
Cell metabolism - 7 Jan 2014
Flanagan Sarah E, De Franco Elisa, Lango Allen Hana, Zerah Michele, Abdul-Rasoul Majedah M, Edge Julie A, Stewart Helen, Alamiri Elham, Hussain Khalid, Wallis Sam, de Vries Liat, Rubio-Cabezas Oscar, Houghton Jayne A L, Edghill Emma L, Patch Ann-Marie, Ellard Sian, Hattersley Andrew T
Abstract excerpt
Understanding transcriptional regulation of pancreatic development is required to advance current efforts in developing beta cell replacement therapies for patients with diabetes. Current knowledge of key transcriptional regulators has predominantly come from mouse studies, with rare, naturally occurring mutations establishing their relevance in man. This study used a combination of homozygosity analysis and...
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