Article
Congenic rats reveal three independent Copenhagen alleles within the Mcs1 quantitative trait locus that confer resistance to mammary cancer.
Cancer research - 15 Sept 2003
Haag Jill D, Shepel Laurie A, Kolman Bradley D, Monson Dinelli M, Benton Margaret E, Watts Kevin T, Waller Jordy L, Lopez-Guajardo Christine C, Samuelson David J, Gould Michael N
Abstract excerpt
It has previously been shown that the Copenhagen (COP) rat contains several genetic loci that contribute to its mammary tumor-resistant phenotype after 7,12-dimethylbenz(a)anthracene (DMBA) administration. One of these loci, mammary carcinoma susceptibility 1 (Mcs1), is located on the centromeric end of chromosome 2 and appears to act in a semidominant fashion. To confirm the existence and independent action of...
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