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Article

Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex.

The Journal of biological chemistry - 22 May 1998

Popov S, Rexach M, Ratner L, Blobel G, Bukrinsky M

Abstract excerpt

Replication of human immunodeficiency virus type 1 (HIV-1) in non-dividing cells depends critically on import of the viral preintegration complex into the nucleus. Recent evidence suggests that viral protein R (Vpr) plays a key regulatory role in this process by binding to karyopherin alpha, a cellular receptor for nuclear localization signals, and increasing its affinity for the nuclear localization signals. An...

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Identifiers

PMID: 9582382
DOI: 10.1074/jbc.273.21.13347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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