Article
Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice.
The Journal of general virology - 1 Sept 2008
Kimura Takashi, Imamura Michio, Hiraga Nobuhiko, Hatakeyama Tsuyoshi, Miki Daiki, Noguchi Chiemi, Mori Nami, Tsuge Masataka, Takahashi Shoichi, Fujimoto Yoshifumi, Iwao Eiji, Ochi Hidenori, Abe Hiromi, Maekawa Toshiro, Arataki Keiko, Tateno Chise, Yoshizato Katsutoshi, Wakita Takaji, Okamoto Toru, Matsuura Yoshiharu, Chayama Kazuaki
Abstract excerpt
The establishment of clonal infection of hepatitis C virus (HCV) in a small-animal model is important for the analysis of HCV virology. A previous study developed models of molecularly cloned genotype 1a and 2a HCV infection using human hepatocyte-transplanted chimeric mice. This study developed a new model of molecularly cloned genotype 1b HCV infection. A full-length genotype 1b HCV genome, HCV-KT9, was cloned...
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