Article
Antibody-directed superantigen-mediated T-cell killing of myeloid leukaemic cell line cells.
European journal of haematology - 1 Apr 1998
Gidlöf C, Carlson B, Dohlsten M, Tötterman T H
Abstract excerpt
Bacterial superantigens (SAgs) bound to MHC class II molecules on target cells are efficient activators of cytotoxic T cells expressing certain T cell receptor (TCR) Vbeta regions We described earlier that the specificity of the SAg Staphylococcus enterotoxin A (SEA) can be changed by introducing...
Topics
- Antibodies, Monoclonal
- Antibody-Dependent Cell Cytotoxicity
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Cell Line
- HL-60 Cells
- Humans
- Leukemia, Myeloid
- Phenotype
- Sialic Acid Binding Ig-like Lectin 3
- Stimulation, Chemical
- Superantigens
- T-Lymphocytes
- T-Lymphocytes, Cytotoxic
- Tumor Necrosis Factor-alpha