Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improved stability and yield of Fv targeted superantigen by introducing both linker and disulfide bond into the targeting moiety.

Biochimie - 1 Aug 2005

Hao Huai-Jie, Jiang Yong-Qiang, Zheng Yu-Ling, Ma Ru, Yu Duo-Wei

Abstract excerpt

Bacterial superantigens (SAg) are the most potent activators of human T lymphocytes and recombinant immunotoxin using bacterial SAg shows promising clinical values. To engineer superantigen for immunotherapy of hepatocellular carcinoma, we genetically fused the superantigen staphylococcus enterotoxin A (SEA(D(227)A)) to the single-chain disulfide-stabilized Fv (scdsFv) of anti-hepatoma monoclonal antibody HAb25...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Affinity
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disulfides

Share to Drug Stability

Share to Enterotoxins

Share to Immunoglobulin Fragments

Share to Immunotoxins

Share to Superantigens

Source

Identifiers

PMID: 15927340
DOI: 10.1016/j.biochi.2005.04.005

Genes

SEA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improved stability and yield of Fv targeted superantigen by introducing both linker and disulfide bond into the targeting moiety.PMID 15927340Read ↗

Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1.Semantic proximity Read ↗

A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.Semantic proximity Read ↗

Superantigens, a Paradox of the Immune ResponseSemantic proximity Read ↗

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity.Semantic proximity Read ↗

Evaluation of a recombinant double mutant of staphylococcal enterotoxin B (SEB-H32Q/K173E) with enhanced antitumor activity effects and decreased pyrexia.Semantic proximity Read ↗

Development of engineered vaccines effective against structurally related bacterial superantigensSemantic proximity Read ↗

An immunoinformatics approach for the design of a multi-epitope vaccine targeting super antigen TSST-1 of Staphylococcus aureusSemantic proximity Read ↗

Structure of the staphylococcal enterotoxin B vaccine candidate S19 showing eliminated superantigen activity.Semantic proximity Read ↗

Antibodies are capable of directing superantigen-mediated T cell killing of chronic B lymphocytic leukemia cells.Semantic proximity Read ↗

Vaccinomics Approach for Designing Potential Peptide Vaccine by TargetingShigellaspp. Serine Protease Autotransporter Subfamily Protein SigASemantic proximity Read ↗

Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.Semantic proximity Read ↗

Superantigen vaccines: a comparative study of genetically attenuated receptor-binding mutants of staphylococcal enterotoxin A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.